John Antoniou Selected Research

Collagen Type X

7/2015	The Effects of Naproxen on Chondrogenesis of Human Mesenchymal Stem Cells.
1/2015	Naproxen induces type X collagen expression in human bone-marrow-derived mesenchymal stem cells through the upregulation of 5-lipoxygenase.
7/2014	Naproxen affects osteogenesis of human mesenchymal stem cells via regulation of Indian hedgehog signaling molecules.
4/2013	Effect of acetaminophen and nonsteroidal anti-inflammatory drugs on gene expression of mesenchymal stem cells.
1/2011	Effect of nitrogen-rich cell culture surfaces on type X collagen expression by bovine growth plate chondrocytes.
1/2011	The constitutive expression of type x collagen in mesenchymal stem cells from osteoarthritis patients is reproduced in a rabbit model of osteoarthritis.
11/2010	Effect of parathyroid hormone on type X and type II collagen expression in mesenchymal stem cells from osteoarthritic patients.
9/2010	Novel insights into the mechanism of decreased expression of type X collagen in human mesenchymal stem cells from patients with osteoarthritis cultured on nitrogen-rich plasma polymers: implication of cyclooxygenase-1.
1/2007	Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy.
9/2006	Suppression of genes related to hypertrophy and osteogenesis in committed human mesenchymal stem cells cultured on novel nitrogen-rich plasma polymer coatings.

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John Antoniou Research Topics

Disease

17	Osteoarthritis 01/2018 - 01/2006
15	Hypertrophy 01/2016 - 10/2005
8	Intervertebral Disc Degeneration 03/2018 - 09/2004
7	Osteolysis 01/2011 - 10/2000
6	Pain (Aches) 03/2018 - 01/2009
4	Inflammation (Inflammations) 01/2016 - 02/2003
4	Infections 12/2014 - 01/2009
4	Arthritis (Polyarthritis) 04/2013 - 08/2002
3	Femoral Neck Fractures 01/2016 - 08/2008
3	Necrosis 05/2005 - 02/2003
2	Fibrosis (Cirrhosis) 01/2017 - 11/2014
2	Venous Thromboembolism 12/2014 - 01/2011
2	Hypersensitivity (Allergy) 01/2009 - 08/2008
1	COVID-19 04/2021
1	Osteoporosis 04/2020
1	Back Pain (Backache) 03/2018
1	Neuralgia (Stump Neuralgia) 03/2018
1	Hyperalgesia 03/2018
1	Wounds and Injuries (Trauma) 01/2017
1	Hemorrhage 10/2016
1	Anemia 11/2015
1	Colonic Neoplasms (Colon Cancer) 01/2014
1	Liver Neoplasms (Liver Cancer) 01/2014
1	Relative Energy Deficiency in Sport 12/2012
1	Cysts 02/2012
1	Plasma Cell Granuloma 02/2012
1	Scoliosis 12/2011
1	Rheumatoid Arthritis 09/2011
1	Congenital Abnormalities (Deformity) 04/2011

Drug/Important Bio-Agent (IBA)

12	Collagen Type XIBA 07/2015 - 10/2005
11	MetalsIBA 02/2012 - 01/2002
5	CollagenIBA 01/2018 - 01/2006
5	IonsIBA 02/2009 - 02/2003
4	Collagen Type II (Type II Collagen)IBA 05/2012 - 01/2006
4	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2011 - 10/2005
4	NitrogenIBA 01/2011 - 09/2006
3	CytokinesIBA 03/2018 - 10/2005
3	Peptides (Polypeptides)IBA 03/2018 - 09/2014
3	Biological ProductsIBA 11/2014 - 10/2011
3	Aggrecans (Aggrecan)IBA 04/2013 - 08/2006
3	Collagenases (Collagenase)FDA Link 05/2012 - 01/2007
3	ProstaglandinsIBA 07/2010 - 01/2006
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2007 - 01/2002
2	Diphosphonates (Bisphosphonates)IBA 04/2020 - 01/2003
2	Proteoglycans (Proteoglycan)IBA 01/2018 - 12/2012
2	Dinoprostone (PGE2)FDA Link 01/2017 - 01/2007
2	MineralsIBA 12/2012 - 12/2011
2	Peptide Hydrolases (Proteases)FDA Link 05/2012 - 10/2005
2	Polyethylene (Polythene)IBA 02/2012 - 01/2002
2	CobaltIBA 01/2011 - 05/2005
2	PolymersIBA 09/2010 - 09/2006
2	Matrix Metalloproteinases (MMPs)IBA 07/2008 - 01/2007
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2007 - 01/2006
1	Nerve Growth Factor (NGF)IBA 03/2018
1	Nerve Growth Factors (Neurotrophins)IBA 03/2018
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 03/2018
1	Anesthetics (Anesthetic Agents)IBA 01/2018
1	Small Interfering RNA (siRNA)IBA 01/2017
1	IronIBA 01/2016
1	Deferoxamine (Desferal)FDA LinkGeneric 01/2016
1	Chelating AgentsIBA 01/2016
1	ChemokinesIBA 09/2015
1	EicosanoidsIBA 11/2014
1	Naproxen (Naprosyn)FDA LinkGeneric 07/2014
1	Pharmaceutical PreparationsIBA 07/2014
1	EugenolIBA 01/2014
1	Starch (Cornstarch)IBA 01/2014
1	Dacarbazine (DIC)FDA LinkGeneric 04/2013
1	OsteocalcinIBA 04/2013
1	Acetaminophen (Paracetamol)FDA LinkGeneric 04/2013
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 04/2013
1	Integrin-Binding SialoproteinIBA 04/2013
1	Alkaline PhosphataseIBA 04/2013
1	Alcian BlueIBA 12/2012
1	Cathepsin KIBA 05/2012
1	Dichlorodiphenyldichloroethane (DDD)IBA 12/2011
1	Chemokine CCL20IBA 09/2011
1	Chemokine ReceptorsIBA 09/2011
1	AnticoagulantsIBA 01/2011
1	Chromium AlloysIBA 01/2011
1	Protein Kinases (Protein Kinase)IBA 11/2010
1	Parathyroid Hormone (Parathormone)IBA 11/2010
1	Cyclooxygenase 1IBA 09/2010
1	LipoxinsIBA 07/2010
1	Leukotriene B4IBA 07/2010
1	Analgesics (Analgesic Drugs)IBA 06/2009
1	Dexamethasone (Maxidex)FDA LinkGeneric 06/2009

Therapy/Procedure

10	Hip Replacement Arthroplasty (Total Hip Replacement) 01/2018 - 08/2005
7	Arthroplasty 04/2011 - 10/2000
3	Therapeutics 03/2018 - 07/2014
3	Knee Replacement Arthroplasty (Total Knee Replacement) 10/2016 - 06/2009
1	Orthopedic Procedures 04/2021
1	Fracture Fixation 04/2020
1	Punctures 01/2018
1	Hemiarthroplasty 01/2016
1	Length of Stay 11/2015
1	Erythrocyte Transfusion 12/2014
1	Drug Therapy (Chemotherapy) 11/2014
1	Reoperation 02/2012
1	Ligation 09/2011